Partners in Progress

Atmospheric Pressure Mass Spectrometry

MALDI Atmospheric Pressure Mass Spectrometry

The MassTech™ Atmospheric-Pressure Matrix-Assisted Laser-Desorption Ionisation (AP-MALDI) source enables mass spectrometers fitted with an electrospray or nanospray source to have the additional capability of MALDI. It is called AP-MALDI because, unlike vacuum MALDI, ionisation takes place under atmospheric conditions. This provides several important advantages including convenience, speed of analysis, simplicity of operation and cost

alt text

caption text

AP-MALDI source

AP-MALDI source on a Thermo LTQ-FTMS

enlarge image

Data from AP-MALDI source

BSA digest spectrum from AP-MALDI fitted onto Thermo LTQ

enlarge image


  • Change between MALDI and ESI/nanospray in minutes. Calibrate in ESI and switch to MALDI without recalibration. Sample plates loaded in seconds as there is no waiting for vacuum to be achieved
  • MS-MS and MSn data (if instrumental capabilities permit) from a MALDI source for enhanced sequencing information at a fraction of the cost of a TOF-TOF instrument
  • Robotic control of MALDI targets with CCTV point-and-click visual alignment checking for confidence in operation
  • Imaging acquisition and processing software for MALDI-imaging of tissues and other surfaces
  • Can be fitted to instruments from Thermo, Bruker, Agilent, ABI, Varian and JEOL

alt text

PDF unit with 1 KHz Nd-YAG laser

enlarge image
  • All solid-state Nd-YAG laser for longer lifetime and stability
  • 200 Hz laser repetition rate for minimum analysis time
  • Software-controlled energy attenuation for enhanced reproducibility
  • 1 KHz repetition rate for MALDI imaging
  • Sub-100 micron spot size for high-resolution imaging
  • Raster or pixel-imaging data capture
Contact Us


+44 (0) 1270 763471



KR Analytical Ltd
77 Forge Fields
CW11 3RN