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Atmospheric Pressure Mass Spectrometry

MALDI Atmospheric Pressure Mass Spectrometry

The MassTech™ Atmospheric-Pressure Matrix-Assisted Laser-Desorption Ionisation (AP-MALDI) source enables mass spectrometers fitted with an electrospray or nanospray source to have the additional capability of MALDI. It is called AP-MALDI because, unlike vacuum MALDI, ionisation takes place under atmospheric conditions. This provides several important advantages including convenience, speed of analysis, simplicity of operation and cost

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Leaders in the design and production of AP-MALDI sources

AP-MALDI UHR source on ThermoFisher Scientifc LTQ Velos

AP-MALDI UHR source on ThermoFisher Scientific LTQ-Velos

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Lipids in mouse brain

Data achieved on LTQ-Orbitrap at 10 micron lateral resolution. Data courtesy of Dr. Gilles Frache Luxembourg Institute of Science and Technology

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Features

  • Change between MALDI and ESI/nanospray in minutes. Calibrate in ESI and switch to MALDI without recalibration. Sample plates loaded in seconds as there is no waiting for vacuum to be achieved
  • MS-MS and MSn data (if instrumental capabilities permit) from a MALDI source for enhanced sequencing information at a fraction of the cost of a TOF-TOF instrument
  • Robotic control of MALDI targets with CCTV point-and-click visual alignment checking for confidence in operation
  • Imaging acquisition and processing software for MALDI-imaging of tissues and other surfaces
  • Can be fitted to instruments from Thermo,Agilent and Sciex
  • Custom sources on request
Lipids in mouse brain Lipids in mouse brain

Lipids in mouse brain. Data achieved on LTQ-Orbitrap at 10 micron lateral resolution. Data courtesy of Dr. Gilles Frache Luxembourg Institute of Science and Technology

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Sub-AP-MALDI UHR source and ion funnel

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AP-MALDI- UHR
  • All solid-state 10Kz Nd-YAG laser for longer lifetime and stability
  • Spot sizes of 10 micron or less
  • Click and point software for simple acquisition
  • Images produced compare with the quality of data from expensive dedicated MALDI mass spectrometers
Sub- AP-MALDI
  • As above but with the addition of an ion-funnel for increased sensitivity at small spot sizes
  • Operates at 1-Torr for 10 - 100 x increase in sensitivity compared to atmospheric systems
  • Raster or pixel-imaging data capture
 
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KR Analytical Ltd
77 Forge Fields
Sandbach
Cheshire
CW11 3RN
UK