Mass Spectrometers

Atmospheric-Pressure MALDI

The Atmospheric-Pressure Matrix-Assisted Laser-Desorption Ionisation (AP-MALDI) source enables mass spectrometers fitted with an electrospray or nanospray source to have the additional capability of MALDI. It is called AP-MALDI because, unlike vacuum MALDI, ionisation takes place under atmospheric conditions. This provides several important advantages including convenience, speed of analysis, simplicity of operation and cost.

New for 2007! - Existing AP-MALDI users can now upgrade existing nitrogen lasers to the new Nd-YAG laser -see below for more details

Features
	Change between MALDI and ESI/nanospray in minutes. Calibrate in ESI and switch to MALDI without recalibration. Sample plates loaded in seconds as there is no waiting for vacuum to be achieved.
	MS-MS and MSⁿ data (If instrumental capabilities permit) from a MALDI source for enhanced sequencing information at a fraction of the cost of a TOFTOF instrument.
	Superior performance, simpler operation and more reliable MS-MS capability than MALDI-TOF post-source decay (PSD)
	Robotic control of MALDI targets with CCTV point-and-click visual alignment checking for confidence in operation
	Windows control software interfaces seamlessly with existing control and acquisition software provided by instrument manufacturer to make operation simple.
	Versions available for Thermo-Finnigan Classic, Duo, Deca, Deca XP Deca XP Advantage and LTQ linear trap LTQ-FTMS and Orbitrap; Bruker ion-traps and FTMS, Waters/Micromass Q-TOF and LCT, ABI QTraps, Shimadzu QIT and the Varian 500 LC-MS ion trap.

The MassTech AP-MALDI source as fitted to a Thermo-Finnigan LTQ-FTMS.

AP-MALDI data at 200,000 RP of BSA digest from a Thermo LTQ-FTMS.

Click here for larger image

New Nd-YAG Laser

The third-generation versions of the AP-MALDI source are fitted with the new all solid-state Nd-YAG laser. This has several advantages over the nitrogen laser versions.

Features
	Integrated pulsed-dynamic-focussing (PDF) for maximum sensitivity
	All solid-state Nd-YAG laser guaranteed for 1 billion firings for increased reliability and low cost-of-ownership
	Up to 200 Hz repetition rate for higher throughput and faster imaging
	Software-controlled attenuation for more reproducible analyses

New Software and Sample Capabilities

The latest version of the Target software includes many enhancements.

Features
	New raster pattern motion with precise control of stage speed for MALDI imaging
	Automated recognition of target spot centres to complement automatic sample-spotting devices
	New sample plate holders including dense 384-spot plates, ABI Opti-TOF 192-spot plates and Waters DIOS plates

For further details on any of these products contact KR Analytical.