If a sample can be analysed at atmospheric pressure and not under vacuum, analysis time is greatly reduced because it is not necessary to wait for the sample region to pump down. Furthermore, biological samples can be analysed in conditions closer to their natural environment.

Several ionisation techniques are now available to utilise this advantage.

DART, Direct Analysis in Real Time requires minimal sample preparation. Simply position the sample in the gas stream and produce spectra.

 Atmospheric-Pressure MALDI has all the sensitivity of conventional vacuum MALDI but because it is not necessary for the sample to be under vacuum, changing sample plates takes a few seconds, greatly reducing analysis time. 

Atmospheric Pressure Photo-Ionisation APPI, is capable of ionising non-polar molecules that are not readily ionised by electrospray and so provides a complementary technique for the analytical laboratory.

Atmospheric Pressure MALDI >>

DART >>

APPI >>